Scrotal eczema-like lesion of secondary syphilis in an HIV-positive patient.

Sir, Unusual clinical infections may be observed in patients with human immunodeficiency virus (HIV) infection (1). Due to diverse clinical and histopathological presentations, the diagnosis of syphilis can occasionally prove challenging (2). Secondary syphilis, which has protean manifestations in fully immunocompetent individuals, may present even greater diagnostic challenges in HIV seropositive patients. A variable clinical presentation of secondary syphilis in HIV disease may result in an incorrect diagnosis and treatment (3–6). We observed a case of scrotal eczema-like lesion of secondary syphilis with HIV infection with features not previously described.